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Don’t let cold sores take away your confidence. Tackle the source of your cold sore right from the first tingle.The product of years of rigorous scientific study, Abreva cream works by penetrating deep into the skin to the source of the spreading virus that causes cold sores. When used at the first sign, it blocks the cold sore virus from entering surrounding cells and reduces the duration of pain, burning, itching and/or tingling.