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Abreva: Cold Sore Treatment Cream. Abreva contains docosanol, real medicine that is clinically proven to shorten the duration of the cold sore and shorten the duration of the symptoms associated with cold sores. It helps reduce the duration of burning, itching, tingling, and pain so you can get back to living your life. Abreva works best if you start treatment at the first sign of a cold sore or fever blister outbreak – when you feel that tingling sensation and continue applying it as directed five times per day until the cold sore is healed up to a maximum of 10 days. The sooner you catch it, the better your chances for speeding cold sore healing. Abreva is Canada’s #1 Pharmacist recommended OTC cold sore remedy. Docosanol 10% Cream.