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Tylenol Arthritis Pain Acetaminophen Caplets - 100's* are formulated to provide effective relief from minor arthritis and joint pain. Each caplet contains 650 mg of acetaminophen in a dual-layer design: the first layer dissolves quickly for fast-acting relief, while the second layer releases acetaminophen gradually for up to 8 hours of extended relief. This extended-release formulation is gentle on the stomach, making it suitable for long-term use when taken as directed. Tylenol is a trusted brand, recommended by healthcare professionals for its safety and efficacy in managing arthritis pain.