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Description PROMOGRAN™ Protease Modulating Matrix is comprised of a sterile, freeze-dried composite of 45% oxidized regenerated cellulose (ORC) and 55% collagen. Optimum Wound Environment PROMOGRAN™ Matrix maintains an optimal wound healing environment. This environment is conducive to granulation tissue formation, epithelization and rapid wound healing. Maintains an optimum wound healing environment In the presence of exudate, PROMOGRAN™ Matrix transforms into a soft, conformable, biodegradable gel. This allows contact with all areas of the wound. Economic Value An additional retrospective study analyzing cost-effectiveness in the management of neuropathic DFU (n=40), showed that wound Management with PROMOGRAN™ Matrix was more cost-effective per patient over 6 weeks of treatment as compared to standard care (Control).3 Product Description PROMOGRAN™ Matrix is a topically applied interactive wound therapy. The product is a sterile, freeze dried composite of oxidised regenerated cellulose (ORC) and collagen. In the presence of exudate the PROMOGRAN™ Matrix transforms into a soft conformable, biodegradabile gel; this allows contact with all areas of the wound. Saline or Ringer's solution should be used to rehydrate PROMOGRAN™ Matrix on dry wounds. PROMOGRAN™ Matrix modulates and re-balances the wound environment by the unique combination of: Binding and inactivation of proteases (i.e. matrix metallo proteases, elastase and plasmin) which have been shown to be detrimental in excess chronic wounds Binding and protection of naturally occurring growth factors against degradation by these excecess proteases. The naturally occurring, protected growth factors are released back into the wound, while the detrimental proteases remain upon bio-degradation of the PROMOGRAN™ Matrix. PROMOGRAN™ Matrix has demonstrated free radical scavenging properties. Indications for use PROMOGRAN™ Matrix is intended for the management of all wounds healing by secondary intent which are clear of necrotic tissue, including: Diabetic ulcers Venous ulcers Pressure ulcers Ulcers caused by mixed vascular aetiologies Traumatic and surgical wounds PROMOGRAN™ Matrix can be used under compression therapy